Our projects focus on understanding and addressing the challenge of pregnancy loss in various mammalian species, including horses and humans. By studying normal and failing pregnancies in mares, we aim to identify the genetic causes, such as aneuploidy and copy number variation, and explore the mechanisms involved in the development of these variants in the placenta. Ultimately, our goal is to develop new diagnostic tests and treatments that can reduce the incidence of pregnancy loss and improve reproductive outcomes. Features publications are below, with full details on Google Scholar.
Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse
Shilton, CA, Kahler, A, Crabtree, JR, Crowhurst, J, Davis, BW, McGladdery, AJ, Wathes, DC, Raudsepp, T, de Mestre, AM. . Scientific Reports. 2020 Aug 7;10(1):13314
Fetal morphological features and abnormalities associated with equine early pregnancy loss Kahler A, McGonnell IM, Smart H, Kowalski AA, Smith KC, Wathes DC, de Mestre, AM. . Equine Veterinary Journal, 2021 May;53(3):530-541.
Shilton, CA, Kahler, A, Roach, JM, Raudsepp, T, and de Mestre, AM. Reproduction, Fertility, Development, 2022, Dec;35(2):51-69.
First reported case of fragile foal syndrome type 1 in the Thoroughbred caused by PLOD1 c.2032G>A
Grillos, A.S., J.M. Roach, A.M. de Mestre, A. K. Foote, N. B. Kingsley, M.J. Mienaltowski, and R.R. Bellone. Equine Veterinary Journal, 2021, Dec 22. doi: 10.1111/evj.13547.
A method for isolating and culturing placental cells from failed early equine pregnancies
Rose BV, Cabrera-Sharp V, Firth MJ, Barrelet FE, Bate S, Cameron IJ, Crabtree JR, Crowhurst J, McGladdery AJ, Neal H, Pynn J, Pynn OD, Smith C, Wise Z, Verheyen KL, Wathes DC, de Mestre AM. Placenta, 2016 Feb;38:107-11.
Jessica M Lawson # 1, Shebl E Salem # 2, Donald Miller # 2, Anne Kahler 1, Wilhelmina J van den Boer 2, Charlotte A Shilton 1, Tia Sever 2, Rebecca R Mouncey 1, Jenna Ward 2, Daniel J Hampshire 1, Alastair K Foote 3, Jill S Bryan 3, Rytis Juras 4, Oliver D Pynn 5, Brian W Davis 4, Rebecca R Bellone 6 7, Terje Raudsepp 4, Amanda M de Mestre 2
Does inbreeding contribute to pregnancy loss in Thoroughbred horses? - PubMed
Jessica M Lawson 1, Charlotte A Shilton 2, Victoria Lindsay-McGee 3, Androniki Psifidi 3, D Claire Wathes 1, Terje Raudsepp 4, Amanda M de Mestre 2
Glial Cells Missing 1 regulates equine Chorionic Gonadotrophin beta subunit via binding to the proximal promoter
Read JE, Victoria Cabrera-Sharp, Phoebe Kitscha, Judith E Cartwright, Peter J King, Rob C Fowkes and de Mestre AM. Front. Endocrinology, 26 April 2018, 9: 195
Markers of equine placental differentiation: insights from gene expression studies
Loux S, Robles M, Chavatte-Palmer P, de Mestre AM. . Reproduction. 2022 Feb 14;163(3):R39-R54.
Dynamic changes in gene expression and signalling during trophoblast development in the horse
Read JE, Cabrera-Sharp V, Offord V, Mirczuk SM, Allen SP, Fowkes RC, de Mestre AM. Reproduction. 2018 Jul 10. pii: REP-18-0270.
Cabrera-Sharp V, Read JE, Richardson S, Kowalski AA, Antczak DF, Cartwright JE, Mukherjee A, de Mestre AM. Endocrinology 2014 Aug;155(8):3054-64
Glial Cells Missing 1 Is Induced in Differentiating Equine Chorionic Girdle Trophoblast Cells
de Mestre, AM, Miller, D., Roberson, MS., Liford, J., Chizmar, LC., McLaughlin, K.E., and Antczak, D. F. Biology of Reproduction, 2009. 80(2):227
Does inbreeding contribute to pregnancy loss in Thoroughbred horses? - PubMed Jessica M Lawson 1, Charlotte A Shilton 2, Victoria Lindsay-McGee 3, Androniki Psifidi 3, D Claire Wathes 1, Terje Raudsepp 4, Amanda M de Mestre 2
de Mestre AM, BV Rose, YM Chang, DC Wathes, KLP Verheyen. Theriogenology, 2019 Jan 15;124:18-23. doi: 10.1016/j.theriogenology.2018.10.008.
Rose BV, Firth M, Morris B, Roach JM, Wathes DC, Verheyen KLP, de Mestre AM. Anim Reprod Sci, 2018 Jan;188:74-84.
Multivariable analysis to determine the risk factors associated with abortion in Thoroughbred mares
Roach, JM, Arango-Sabogal, JC, Smith. KC, Foote, AK v, Verheyen, KL, de Mestre, AM. Reproduction and Fertility, Nov 1:RAF-22-0087.
Incidence and causes of pregnancy failure after day 70 of gestation in Thoroughbreds
Roach, JM, Foote, AK, Smith. KC, Verheyen, KL., de Mestre, AM. Equine Veterinary Journal, 2021 Sept;53(5):996-1003.
Mixed Effects Modelling of the Risk Factors Associated with Multiple Pregnancies in Thoroughbred Mares
Salem SE, Sinnott A, Roach JM, Vereheyn KLP and de Mestre AM. Animals, 2022 Jul 20;12(14):1841.
Rebecca Mouncey 1, Juan C Arango-Sabogal 1 2, Amanda de Mestre 3, Kristien L Verheyen 1
Gestation Length is Associated With Early-Life Limb Deformities in Thoroughbred Foals - PubMed
Rebecca Mouncey 1, Juan Carlos Arango-Sabogal 2, Amanda M de Mestre 3, Kristien Verheyen 4
Monoclonal antibodies for equine CD25 improve detection of regulatory T cells in horses - PubMed
Bettina Wagner 1, Susanna Babasyan 2, Sophie Wilford 3, Melissa G Robbin 3, Amanda M de Mestre 4
Single-cell atlas of the pregnant equine endometrium before and after implantation† - PubMed
Joanna Jaworska 1, Dawid Tobolski 2, Shebl E Salem 3, Anne Kahler 4, Izabela Wocławek-Potocka 1, Amanda M de Mestre 3 4
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